What is Combimist L inhaler?
Combimist L Inhaler is a short-acting bronchodilator drug. Medicine composition includes levosalbutamol 50 mg and ipratropium bromide 20 mg. The medication is used in the complex treatment and prevention of respiratory failure complications arising from chronic obstructive and emphysematous bronchitis, broncho-pulmonary pathologies characterized by the development of bronchospasm and hypersensitivity of bronchi. Also, the drug can be used for the episodic and systematic treatment of acute attacks of bronchial asthma. The drug improves the patient’s condition by relaxing the muscles in the airways.
Dosage and instructions for use
Combimist L Inhaler must be used orally. Make inhalation up to 3 times a day. The maximum dosage is two inhalations.
Before making inhalation, remove a protective cap from a barrel. If the medicine has not been used for 3 days, then it is necessary to make sure that it is working by means of a test pressing the release button. If an aerosol cloud appears in the air at the same time, then this means that the preparation is ready for use.
First, you need to take a deep breath, then clasp the inhaler tip with your mouth so that its mouthpiece is at the bottom. Then press the bottom of the can and take a deep breath at the same time. After using the inhaler, it is necessary to put on the protective cap again.
During an acute attack of bronchospasm, make 2 inhalations. If you feel no relief after 5 minutes. The lack of improvement after use is the basis for urgent medical help.
- Symptoms: finger tremor, palpitations, tachycardia, a feeling of heaviness in the chest, extrasystole, increased bronchial obstruction;
- Treatment: anxiolytic drugs (tranquilizers), selective beta1-blockers
Combimist L inhaler, like any inhalation therapy, can cause local irritation. Adverse drug reactions were determined on the basis of data obtained in clinical studies.
The most common side effects reported were cough, dry mouth, headache, tremor, pharyngitis, nausea, dizziness, dysphonia, tachycardia, palpitations, vomiting, increased systolic blood pressure and nervousness.
- Immune system: anaphylactic reaction, hypersensitivity, angioedema, hives;
- Metabolism: hypokalemia;
- Nervous system and psyche: nervousness, headache, tremor, dizziness, arousal, mental disturbances;
- Organ of vision: glaucoma, increased intraocular pressure, accommodation disturbances, mydriasis, blurred vision, pain in the eyes, corneal edema, conjunctival hyperemia, appearance of aureole around objects;
- Cardiovascular system: tachycardia, palpitations, increased systolic blood pressure, arrhythmia, atrial fibrillation, supraventricular tachycardia, myocardial ischemia, increased diastolic blood pressure;
- Respiratory system: cough, pharyngitis, dysphonia, bronchospasm, pharynx irritation, pharyngeal edema, laryngospasm, paradoxical bronchospasm, dry pharynx;
- Digestive system: vomiting, nausea, dry mouth, stomatitis, glossitis, gastrointestinal motility disorders, diarrhea, constipation, oral edema;
- Skin and subcutaneous tissues: itching, hyperhidrosis;
- Musculoskeletal system: muscle weakness, muscle spasm, myalgia;
- Urinary system: urinary retention.
Absolute contraindications for Combimist L inhalation are:
- hypertrophic obstructive cardiomyopathy;
- I trimester of pregnancy;
- children’s age up to 6 years;
- hypersensitivity to levosalbutamol and ipratropium bromide.
With caution: children under 6 years, angle-closure glaucoma, coronary insufficiency, hypertension, inadequately controlled diabetes mellitus, recent myocardial infarction, severe organic diseases of the cardiovascular system, hyperthyroidism, pheochromocytoma, hypertrophy of the prostate gland, obstruction of the stomach.
Simultaneous use with xanthine derivatives, cromoglicic acid and GCS enhances the effect, with beta-blockers – weakens. Xanthine derivatives, corticosteroids and diuretics enhance hypokalemia. Halogenated hydrocarbon drugs for general anesthesia (halothane, trichloroethylene, enflurane) increase the risk of cardiovascular side effects. MAO inhibitors, tricyclic antidepressants increase beta-2 stimulation.
Before using Combimist L inhaler, tell your doctor if you have heart disease, high blood pressure, congestive heart failure, heart rhythm disorder, epilepsy, diabetes, or thyroid hyperactivity. Tell your doctor about any medications you use, especially heart drugs or blood pressure drugs, diuretics, antidepressants, or other inhaled bronchodilators.
It is not recommended to use the drug during pregnancy and lactation without consulting a doctor.
If you have an unexpected rapid increase in shortness of breath (difficulty breathing), you should immediately consult a doctor.
Studies of the effects of the drug on the ability to drive and use of mechanisms were not conducted. However, patients need to be informed that during treatment with this medication they may experience such undesirable sensations as dizziness, tremor, accommodation disturbances of the eyes, mydriasis and blurred vision. Therefore, caution should be recommended when driving or using machinery. If patients experience the above undesirable sensations, they should refrain from such potentially dangerous actions as driving a car or operating machinery.